How Does Ezetemibe, A Cholesterol Lowering Drug Work?

How does ezetemibe, a cholesterol lowering drug work?

Ezetemibe a cholesterol lowering medication lowers blood cholesterol by inhibiting its intestinal absorption by acting on NPC1L1 in the intestinal brush border. NPC1L1 is the phytosterol and cholesterol transporter in the intestinal brush border. Ezetimibe causes a decrease in LDL-Cholesterol by inhibiting this transporter. A combination of ezetimibe with atorvastatin is quite powerful in bringing down cholesterol.