Ezetemibe a cholesterol lowering medication lowers blood cholesterol by inhibiting its intestinal absorption by acting on Niemann-Pick C1Like1 (NPC1L1) in the intestinal brush border. Niemann-Pick C1Like1 (NPC1L1) is the phytosterol and cholesterol transporter in the intestinal brush border. Ezetimibe causes a decrease in LDL-Cholesterol by inhibiting this transporter. A combination of ezetimibe with atorvastatin is quite powerful in bringing down cholesterol.
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